CHEMICAL & BIOMOLECULAR ENGINEERING
Published in Cancer Research (2021)
In this review, my colleagues and I review the landscape of using macrophages as anticancer treatments. In addition to highlighting efforts to alter the TME by targeting tumor-associated macrophages, we focus on approaches which directly engineer macrophages to perform anti-tumor functions. CAR macrophages, which was a previous paper, are discussed in depth and contrasted with CAR T cells for the treatment of solid tumors.
Find this paper on PubMed!
The 2018 AIChE national meeting in Pittsburgh was a really great opportunity to see some of the work that is going to be impacting us in the future. There was some really great work on biomaterials on Monday and Tuesday. Wednesday and Thursday had some absolutely amazing work on anti-cancer therapeutics, as well as computational models of biological systems.
I especially want to thank everyone that came out to see my presentation, which will be posted here as soon as the manuscript is published!
Today, of course, was the 2018 Penn CBE Graduate Student Symposium. There was quite a bit of really great discussions about all kinds of research going on in the department. I especially want to thank everyone that came by my poster and listened to my talk. As the work presented is still unpublished, I will not be posting a copy of the presentation immediately. However, you can be sure that once it is published it will be posted.
It finally feels as though I am getting the hang of this, as this time the paper I’m posting is actually new! I have a new second-author paper with Amy Bendell in Annals of Biomedical Engineering about substrate geometry sensing in dentritic cells. I’ve posted a short description of the work here. I hope you take the time to read it. It’s really an awesome story!
I apologize for the delay in posting this but I am proud to announce a new first author paper out for me. Along with Dooyoung Lee and Dan Hammer, I probed the effect of surface densities of different ligand types on the resulting motion of CD4+ T cells. It was published in Cell and Biomolecular Engineering. A more in depth overview of the article can be found here.
I am excited to announce that my paper with Alex Buffone and Dan Hammer has been accepted for publication at the Journal of Cell Science. It’s about the response of HSPCs to shear flow. You can see a short summary of the paper here.
On September 15, I had the great pleasure of presenting some of my work at the 2017 Penn CBE Graduate Student Symposium (GSS). This symposium is a chance for grad students like myself to present to and network with representatives from industry as well as our fellow students. I was lucky enough to present both a talk and a poster this year. I greatly enjoyed speaking to everyone there and got a lot of great questions regarding my work. Unfortunately, I can’t post the work quite yet, as it is still in the process of being published. However, once the paper is accepted, I’ll make sure to update the site with that information under the appropriate areas. If I didn’t get a chance to see you this year, I hope to see you around in 2018 (assuming I’m still around)!
Update (5/17/2018): As mentioned in the new blog post for today, this work has been published in Cellular and Molecular Bioengineering and can be read about here.
Nicholas R. Anderson 