Published in Nature Biotechology (2020)
I was fortunate enough to be a co-author on this paper with the co-founder of Carisma Therapeutics, Mike Klichinsky. In this paper, we showed that macrophages could be transduced with a chimeric Ad5f35 adenovirus to express a first generation CAR. This CAR is active and causes the phagocytosis and killing of target postive tumor cells, while also stimulating pro-inflamatory cytokine release upon antigen stimulation. This promotes tumor clearance in vitro and in vivo, while also converting the TME from “cold” to “hot.”
Nicholas R. Anderson 
One Reply to “”