Published in: Biophysical Journal (2019)
This paper, written by my collaborator Alex Buffone, extends the paradigm of upstream migration in immune cells to neutrophils. Previous studies had suggested that these cells did not migrate upstream on ICAM-1 like other immune cells. Through the use of blocking antibodies and engineered surfaces, we proved that these cells will migrate upstream if Mac-1 is blocked. We believe that Mac-1 acts as a sink for ICAM-1, which prevents the engagement of LFA-1 and the resulting upstream migration.
Nicholas R. Anderson 