The direction of migration of T-lymphocytes under flow depends upon which adhesion receptors are engaged
Published in: Integrative Biology (2015)
This study shows that activated T cells use the direction of flow and the identity of the adhesive ligand to determine in which direction the cell should migrate. On VCAM-1-functionalized surfaces, T cells migrate with the direction of flow, while they migrate upstream on ICAM-1-functionalized surfaces. In addition, we showed that this directionality is mediated by the beta-2 integrin of LFA-1.
Nicholas R. Anderson 