Motile Dendritic Cells Sense and Respond to Substrate Geometry

Published in: Annals of Biomedical Engineering (2018)

This paper, which I am a second author on, was originally going to be about the forces exerted by dendritic cells under certain conditions. However, we found that on the force detectors the cells migrated differently compared to cells on a flat surface. What we found instead was evidence that dendritic cells can sense the geometry of the substrate they are on. For example, we found rings of actin around the tips of posts sticking up from the surface, but did not see similar rings on flat surfaces containing adhesive ligands. Overall, quite the interesting paper!

Find this article on PubMed!

DOI: 10.1007/s10439-018-2041-7

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