It finally feels as though I am getting the hang of this, as this time the paper I’m posting is actually new! I have a new second-author paper with Amy Bendell in Annals of Biomedical Engineering about substrate geometry sensing in dentritic cells. I’ve posted a short description of the work here. I hope you take the time to read it. It’s really an awesome story!
Motile Dendritic Cells Sense and Respond to Substrate Geometry
Published in: Annals of Biomedical Engineering (2018)
This paper, which I am a second author on, was originally going to be about the forces exerted by dendritic cells under certain conditions. However, we found that on the force detectors the cells migrated differently compared to cells on a flat surface. What we found instead was evidence that dendritic cells can sense the geometry of the substrate they are on. For example, we found rings of actin around the tips of posts sticking up from the surface, but did not see similar rings on flat surfaces containing adhesive ligands. Overall, quite the interesting paper!
Sorry for the delay! New 1st author paper out!
I apologize for the delay in posting this but I am proud to announce a new first author paper out for me. Along with Dooyoung Lee and Dan Hammer, I probed the effect of surface densities of different ligand types on the resulting motion of CD4+ T cells. It was published in Cell and Biomolecular Engineering. A more in depth overview of the article can be found here.
Nicholas R. Anderson 