I am excited to announce that my paper with Alex Buffone and Dan Hammer has been accepted for publication at the Journal of Cell Science. It’s about the response of HSPCs to shear flow. You can see a short summary of the paper here.
Migration against the direction of flow is LFA-1 dependent in human hematopoietic stem and progenitor cells
This study is a continuation and extension of my previously published work with Dominguez and Hammer showing a similar phenomena of migration against the direction of fluid flow. However, instead of T lymphocytes, the cells in this manuscript are hematopoietic stem and progenitor cells, which are a more primitive immune cell type. These results show that possibly many immune cells show a similar behavior, which increases the likelihood that this behavior is serving an important biological purpose.
Nicholas R. Anderson 