Supplemented αMEM/F12-based medium enables the survival and growth of primary ovarian follicles encapsulated in alginate hydrogels

Published in: Biotechnology and Bioengineering (2013)

This work is the first reported instance of a serum-free, defined formulation media for the in vitro culture of ovarian follicles. We show that this media allows for the growth of even primary follicles, which is difficult even for traditional system. Thus this system allows for the study of important factors in the maturation of ovarian follicles in a systematic way.

Read the abstract on PubMed.